Hashizume Hideo
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
J Dermatol. 2004 Aug;31(8):603-9. doi: 10.1111/j.1346-8138.2004.tb00565.x.
Skin aging appears to be the result of both scheduled and continuous "wear and tear" processes that damage cellular DNA and proteins. Two types of aging, chronological skin aging and photoaging, have distinct clinical and histological features. Chronological skin aging is a universal and inevitable process characterized primarily by physiologic alterations in skin function. In this case, keratinocytes are unable to properly terminally differentiate to form a functional stratum corneum, and the rate of formation of neutral lipids that contribute to the barrier function slows, causing dry, pale skin with fine wrinkles. In contrast, photoaging results from the UVR of sunlight and the damage thus becomes apparent in sun-exposed skin. Characteristics of this aging type are dry and sallow skin displaying fine wrinkles as well as deep furrows, resulting from the disorganization of epidermal and dermal components associated with elastosis and heliodermatitis. Understanding of the functions of the skin and the basic principles of moisturizer use and application is important for the prevention of skin aging. Successful treatment of dry skin with appropriate skin care products gives the impression of eternal youth.
皮肤老化似乎是由损害细胞DNA和蛋白质的定期及持续“磨损”过程所致。两种老化类型,即自然皮肤老化和光老化,具有不同的临床和组织学特征。自然皮肤老化是一个普遍且不可避免的过程,主要特征为皮肤功能的生理改变。在这种情况下,角质形成细胞无法正常终末分化以形成功能性角质层,且有助于屏障功能的中性脂质形成速率减慢,导致皮肤干燥、苍白并出现细纹。相比之下,光老化是由阳光中的紫外线辐射引起的,其损伤在暴露于阳光下的皮肤中变得明显。这种老化类型的特征是皮肤干燥、蜡黄,出现细纹以及深皱纹,这是由于与弹性组织变性和日光性皮炎相关的表皮和真皮成分紊乱所致。了解皮肤功能以及保湿剂使用和应用的基本原则对于预防皮肤老化很重要。使用适当的护肤品成功治疗干性皮肤会给人一种永葆青春的印象。