核糖体上的延伸机制：一个大分子机器的动力学

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine.

作者信息

Wintermeyer W, Peske F, Beringer M, Gromadski K B, Savelsbergh A, Rodnina M V

机构信息

Institute of Molecular Biology, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany.

出版信息

Biochem Soc Trans. 2004 Nov;32(Pt 5):733-7. doi: 10.1042/BST0320733.

DOI:10.1042/BST0320733

PMID:15494001

Abstract

Protein synthesis in the cell is performed on ribosomes, large ribonucleoprotein particles, which in bacteria consist of three RNA molecules and over 50 proteins. This review summarizes recent progress in understanding the mechanisms of the elongation phase of protein synthesis. Results from rapid kinetic analysis of elongation reactions are discussed in the light of recent structural data.

摘要

细胞中的蛋白质合成是在核糖体上进行的，核糖体是大型核糖核蛋白颗粒，在细菌中由三个RNA分子和50多种蛋白质组成。本综述总结了在理解蛋白质合成延伸阶段机制方面的最新进展。根据最近的结构数据讨论了延伸反应快速动力学分析的结果。