Chiang Feng-Yu, Lee Ka-Wo, Huang Yin-Feng, Wang Ling-Feng, Kuo Wen-Rei
Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University, Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2004 Sep;20(9):431-6. doi: 10.1016/s1607-551x(09)70181-0.
The purpose of this study was to assess the risk of vocal palsy after thyroidectomy with identification of recurrent laryngeal nerve (RLN) during surgery. In all, 521 patients treated by the same surgeon were enrolled in this study. Temporary and permanent vocal palsy rates were analyzed for patient groups classified according to surgery for primary benign thyroid disease, thyroid cancer, Graves' disease, and reoperation. Measurement of the vocal palsy rate was based on the number of nerves at risk. Twenty-six intentionally sacrificed RLNs were excluded from analysis. Forty patients developed postoperative unilateral vocal palsy. Complete recovery of vocal palsy was documented for 35 of the 37 patients (94.6%) whose RLN integrity had been ensured intraoperatively. Recovery from temporary vocal palsy ranged from 3 days to 4 months (mean, 30.7 days). The overall incidences of temporary and permanent vocal palsy were 5.1% and 0.9%, respectively. The rates of temporary/permanent vocal palsy in groups classified according to underlying disease were 4.0%/0.2% for benign thyroid disease, 2.0%/0.7% for thyroid cancer, 12.0%/1.1% for Graves' disease, and 10.8%/8.1% for reoperation. Surgery for thyroid cancer, Graves' disease, and recurrent goiter were associated with significantly higher vocal palsy rates. Most patients without documented nerve damage during the operation recovered from postoperative vocal palsy. Total lobectomy with routine RLN identification is recommended as a basic procedure in thyroid surgery.
本研究的目的是评估甲状腺切除术中识别喉返神经(RLN)后发生声带麻痹的风险。共有521例由同一位外科医生治疗的患者纳入本研究。对根据原发性良性甲状腺疾病、甲状腺癌、格雷夫斯病和再次手术进行分类的患者组分析暂时性和永久性声带麻痹发生率。声带麻痹发生率的测量基于有风险的神经数量。26条故意切断的RLN被排除在分析之外。40例患者术后发生单侧声带麻痹。术中确保RLN完整的37例患者中有35例(94.6%)声带麻痹完全恢复。暂时性声带麻痹恢复时间为3天至4个月(平均30.7天)。暂时性和永久性声带麻痹的总体发生率分别为5.1%和0.9%。根据基础疾病分类的各组中,暂时性/永久性声带麻痹发生率分别为:良性甲状腺疾病4.0%/0.2%,甲状腺癌2.0%/0.7%,格雷夫斯病12.0%/1.1%,再次手术10.8%/8.1%。甲状腺癌、格雷夫斯病和复发性甲状腺肿手术的声带麻痹发生率显著更高。大多数术中未记录神经损伤的患者术后声带麻痹恢复。建议在甲状腺手术中将常规识别RLN的全叶切除术作为基本手术方式。