有丝分裂和减数分裂中的动粒定向

Kinetochore orientation in mitosis and meiosis.

作者信息

Hauf Silke, Watanabe Yoshinori

机构信息

Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-Ku, Tokyo 113-0032, Japan.

出版信息

Cell. 2004 Oct 29;119(3):317-27. doi: 10.1016/j.cell.2004.10.014.

DOI:10.1016/j.cell.2004.10.014

PMID:15507205

Abstract

Kinetochores are the major point of contact between spindle microtubules and chromosomes. They are assemblies of more than 50 different proteins and take part in regulating and controlling their own interaction with the spindle. We review recent advance in understanding how kinetochores are properly placed onto the chromosome, and how their interaction with the microtubules of the spindle is regulated. Kinetochore orientation in meiosis I shows some particular features, and we also discuss similarities and differences between mitosis and meiosis I.

摘要

动粒是纺锤体微管与染色体之间的主要接触点。它们是由50多种不同蛋白质组成的复合体，参与调节和控制自身与纺锤体的相互作用。我们综述了在理解动粒如何正确定位到染色体上以及它们与纺锤体微管的相互作用如何被调控方面的最新进展。减数分裂I中的动粒定向呈现出一些特殊特征，我们还讨论了有丝分裂和减数分裂I之间的异同。