Th1和Th2细胞因子谱的调节及其与晚期头颈部鳞状细胞癌的关联。

Modulation of Th1 and Th2 cytokine profiles and their association with advanced head and neck squamous cell carcinoma.

作者信息

Sparano Anthony, Lathers Deanne M R, Achille Nicholas, Petruzzelli Guy J, Young M Rita I

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19107, USA.

出版信息

Otolaryngol Head Neck Surg. 2004 Nov;131(5):573-6. doi: 10.1016/j.otohns.2004.03.016.

DOI:10.1016/j.otohns.2004.03.016

PMID:15523428

Abstract

OBJECTIVE

Plasma cytokine concentrations from patients with head and neck squamous cell carcinoma (HNSCC) were measured to determine whether the potential modulation of host Th1 vs Th2 immune responses are associated with advanced clinical disease.

STUDY DESIGN AND SETTING

The concentrations of IL-4, IL-6, IL-10, and IL-12 were measured in the plasma of 58 patients with histologically proven HNSCC. These data were examined with respect to the histologic size (T-stage) of the primary tumor, and presence of nodal metastasis.

RESULTS

The concentrations of IL-12 were greater from patients without nodal metastasis, and with T(1)/T(2)-stage tumors. IL-10 levels were greater from patients with nodal metastasis, and with T(3)/T(4)-stage tumors. The concentrations of IL-6 were greater from patients with T(3)/T(4)-stage tumors.

CONCLUSIONS

Using parameters of primary tumor size and presence of nodal metastasis, patients with advanced HNSCC have significantly less plasma IL-12 levels, and greater plasma IL-10 and IL-6 levels.

SIGNIFICANCE

Patients with advanced HNSCC have a potentially diminished Th1 immune response, and a stronger potential Th2 immune response when compared to that of patients with less advanced disease.