细胞色素P4501A1基因多态性与成年墨西哥患者急性淋巴细胞白血病的易感性相关。

Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients.

作者信息

Gallegos-Arreola M P, Batista-González C M, Delgado-Lamas J L, Figuera L E, Puebla-Pérez A M, Arnaud-López L, Peralta-Leal V, Ramírez-Jirano L J, Zúñiga-González G M

机构信息

División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco, México.

出版信息

Blood Cells Mol Dis. 2004 Nov-Dec;33(3):326-9. doi: 10.1016/j.bcmd.2004.07.002.

DOI:10.1016/j.bcmd.2004.07.002

PMID:15528152

Abstract

We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients. Distributions of CYP1A1 Val/Val genotypes in peripheral blood DNA samples from 136 healthy controls and 136 adult patients with ALL were evaluated. There was an increased frequency of the CYP1A1 Val/Val genotype among ALL patients, showing a significant association between this genotype and the risk of developing ALL.

摘要

我们研究了细胞色素P4501A1（CYP1A1 Val/Val）基因型在成年墨西哥患者急性淋巴细胞白血病（ALL）病因中的作用。评估了136名健康对照者和136名成年ALL患者外周血DNA样本中CYP1A1 Val/Val基因型的分布情况。ALL患者中CYP1A1 Val/Val基因型的频率增加，表明该基因型与发生ALL的风险之间存在显著关联。