[实时荧光定量聚合酶链反应检测羊水对先天性风疹感染产前诊断的诊断价值评估]
[Assessment of the diagnostic value of RT-PCR on amniotic fluid for prenatal diagnosis of congenital rubella infection].
作者信息
Macé M, Cointe D, Six C, Levy-Bruhl D, Parent du Chatelet I, Ingrand D, Grangeot-Keros L
机构信息
Service de microbiologie-immunologie biologique, hôpital Antoine-Béclère, 92141 Clamart, France.
出版信息
Pathol Biol (Paris). 2004 Nov;52(9):540-3. doi: 10.1016/j.patbio.2004.06.004.
AIM OF THE STUDY
To assess the diagnostic value of RT-PCR on amniotic fluid (AF) for prenatal diagnosis of congenital rubella infection.
MATERIAL AND METHODS
RT-PCR on AF was compared to specific IgM antibody detection in foetuses and/or newborns in 45 pregnant women with confirmed primary infection.
RESULTS
specificity of RT-PCR was 100% and sensitivity ranged between 83 and 95%.
CONCLUSION
RT PCR may be considered as a valuable tool for prenatal diagnosis of foetal rubella infection.
研究目的
评估羊水逆转录聚合酶链反应（RT-PCR）对先天性风疹感染产前诊断的价值。
材料与方法
对45例确诊为原发性感染的孕妇，将羊水RT-PCR检测结果与胎儿和/或新生儿特异性IgM抗体检测结果进行比较。
结果
RT-PCR的特异性为100%，敏感性在83%至95%之间。
结论
RT-PCR可被视为胎儿风疹感染产前诊断的一种有价值的工具。
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