Sempere A P, Callejo-Domínguez J M, García-Clemente C, Ruipérez-Bastida M C, Mola-Caballero de Roda S, García-Barragán N, Vela-Yebra R, Flores-Ruiz J J
Sección de Neurología, Hospital Vega Baja, Orihuela, Alicante, Spain.
Rev Neurol. 2004;39(9):807-10.
The purpose of this study was to analyse the cost effectiveness of the complementary tests in the diagnosis of reversible causes of dementia in an extra-hospital Neurology service.
Patients referred to the Neurology service from Primary Care with a diagnosis of dementia according to DSM-III-R criteria. The following routine complementary tests were performed: 1. Analyses, including blood count, biochemical study, vitamin B12 and folic levels, thyroid hormones, and syphilis serodiagnosis; 2. Neuroimaging study, consisting in computerised axial tomography or cranial magnetic resonance.
A total of 269 consecutive patients diagnosed as suffering from dementia were included in the study. The mean age of the patients was 74.5 years (49-94 years) and 61% were females. The most frequent cause of dementia was Alzheimer's disease (79.9%). In all, 31 patients presented potentially reversible conditions (11.5%), but if we exclude depression, the dementia was only reversible in one patient (0.4%).
The percentage of patients with reversible causes of dementia in the field of extra-hospital neurology is low. The diagnostic study must be individualised according to the clinical suspicion.
本研究旨在分析在院外神经科服务中用于诊断可逆性痴呆病因的补充检查的成本效益。
根据DSM-III-R标准,由初级保健机构转诊至神经科服务且诊断为痴呆的患者。进行了以下常规补充检查:1. 分析检查,包括血细胞计数、生化研究、维生素B12和叶酸水平、甲状腺激素以及梅毒血清学诊断;2. 神经影像学检查,包括计算机断层扫描或头颅磁共振成像。
本研究共纳入269例连续诊断为痴呆的患者。患者的平均年龄为74.5岁(49 - 94岁),61%为女性。最常见的痴呆病因是阿尔茨海默病(79.9%)。共有31例患者存在潜在可逆性情况(11.5%),但如果排除抑郁症,仅1例患者的痴呆是可逆的(0.4%)。
院外神经科领域中痴呆病因可逆的患者比例较低。诊断研究必须根据临床怀疑进行个体化。