Jermini-Gianinazzi I, Luethy R, Gubler J
Medizinische Klinik, Stadtspital Triemli Zürich.
Praxis (Bern 1994). 2004 Oct 20;93(43):1781-4. doi: 10.1024/0369-8394.93.43.1781.
Right upper quadrant pain with chronic malaise and fever can be the clinical manifestation of a hepatic infection. An uncommon cause for the disease is hepatic actinomycosis. Actinomycosis was common in the preantibiotic era but is less frequent nowadays; consequently its timely recognition has become more difficult. The clinical and radiological findings often resemble other inflammatory and neoplastic lesions. We report a case of a mixed anaerobic liver abscess including fusobacteria and actinomycetes, without apparent predisposing factor. The diagnosis was obtained by CT-guided percutaneous aspiration of the hepatic mass, where microscopy revealed the presence of fusiform gramnegative bacteria and gram-positive branching filamentous rods consistent with Actinomyces species. The latter did not grow in culture, while the gram negatives were identified as fusobacterium nucleatum. The diagnosis of actinomycosis of the liver is confirmed in only a minority of cases by culture. The disease is usually treated with an extended course of antibiotics. Penicillin is the preferred choice.
右上腹疼痛伴慢性不适和发热可能是肝脏感染的临床表现。肝放线菌病是该病的一种罕见病因。放线菌病在抗生素时代之前很常见,但如今发病率较低;因此,及时识别该病变得更加困难。其临床和影像学表现常与其他炎症性和肿瘤性病变相似。我们报告一例混合性厌氧性肝脓肿病例,包含梭杆菌和放线菌,无明显诱发因素。通过CT引导下经皮穿刺抽吸肝脏肿块进行诊断,显微镜检查发现存在梭形革兰氏阴性菌和与放线菌属一致的革兰氏阳性分支丝状杆菌。后者在培养中未生长,而革兰氏阴性菌被鉴定为具核梭杆菌。仅少数病例通过培养确诊肝放线菌病。该病通常采用延长疗程的抗生素治疗。青霉素是首选药物。