复制囊泡作为原始细胞生长和分裂的模型。

Replicating vesicles as models of primitive cell growth and division.

作者信息

Hanczyc Martin M, Szostak Jack W

机构信息

Howard Hughes Medical Institute, Department of Molecular Biology, Mass. General Hospital, Boston, MA 02114, USA.

出版信息

Curr Opin Chem Biol. 2004 Dec;8(6):660-4. doi: 10.1016/j.cbpa.2004.10.002.

DOI:10.1016/j.cbpa.2004.10.002

PMID:15556412

Abstract

Primitive cells, lacking the complex bio-machinery present in modern cells, would have had to rely on the self-organizing properties of their components and on interactions with their environment to achieve basic cellular functions such as growth and division. Many bilayer-membrane vesicles, depending on their composition and environment, can exhibit complex morphological changes such as growth, fusion, fission, budding, internal vesicle assembly and vesicle-surface interactions. The rich dynamic properties of these vesicles provide interesting models of how primitive cellular replication might have occurred in response to purely physical and chemical forces.

摘要

原始细胞缺乏现代细胞中存在的复杂生物机制，它们必须依靠其组成部分的自组织特性以及与环境的相互作用来实现诸如生长和分裂等基本细胞功能。许多双层膜囊泡，根据其组成和环境，可表现出复杂的形态变化，如生长、融合、裂变、出芽、内部囊泡组装和囊泡表面相互作用。这些囊泡丰富的动态特性为原始细胞复制如何可能响应纯粹的物理和化学力量而发生提供了有趣的模型。