通过使芽殖酵母中的分离酶失活来发现新的细胞周期相关蛋白
Uncovering novel cell cycle players through the inactivation of securin in budding yeast.
作者信息
Sarin Sumeet, Ross Karen E, Boucher Lorrie, Green Yvette, Tyers Mike, Cohen-Fix Orna
机构信息
The Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0840, USA.
出版信息
Genetics. 2004 Nov;168(3):1763-71. doi: 10.1534/genetics.104.029033.
Abstract
Budding yeast securin/Pds1p, an inhibitor of the anaphase activator separase/Esp1p, is involved in several checkpoint pathways and in promoting Esp1p's nuclear localization. Using a modified synthetic genetic array (SGA) screen for genes that become essential in the absence of Pds1p, we uncovered roles for uncharacterized genes in cell cycle processes, including Esp1p activation.
摘要
出芽酵母中的securin/Pds1p是后期激活因子分离酶/Esp1p的一种抑制剂，它参与多种检查点途径并促进Esp1p的核定位。我们利用改良的合成基因阵列（SGA）筛选在缺乏Pds1p时变得必不可少的基因，从而揭示了一些未被鉴定的基因在细胞周期过程中的作用，包括Esp1p的激活。
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