Astl Jaromír, Veselý David, Matucha Petr, Martínek Jindrich, Kucera Tomás, Lastuvka Petr, Betka Jan, Sterzl Ivan
Department of Otorhinolaryngology, Head and Neck Surgery. The First Medical Faculty of the Charles University in Prague, University Hospital Motol, Czech Republic.
Neuro Endocrinol Lett. 2004 Oct;25(5):356-60.
HGF (Hepatocyte Growth Factor), TGFbeta1 (Transforming Growth Factor beta1) and IGF-I (Insulin Like Growth Factor I) are cytokines that are involved in the parathyroid tumors formation and growth. We tried to determine, if there are changes and relationships in the production of these cytokines by tumor cells of parathyroid tumors.
We determined concentrations of HGF, TGFbeta1 and IGF-I in serum from peripheral blood of 16 patients with parathyroid adenoma and of 8 patients with parathyroid secondary hyperplasia before and after parathyroidectomy. Results were compared with serum levels in healthy people.
Both preoperative and postoperative HGF serum levels in patients with parathyroid adenoma and secondary hyperplasia are significantly higher than in healthy people. Preoperative and postoperative serum levels of TGFbeta1 in parathyroid adenoma and postoperative TGFb1 serum levels in parathyroid secondary hyperplasia are higher, compared with those in the healthy population and in parathyroid secondary hyperplasia preoperatively. There are no significant differences of IGF-I serum levels among the all investigated groups of patients.
Changes in the growth factors production by parathyroid tumor cells are reflected by their concentrations in peripheral blood. The elevation of HGF serum levels in patients with parathyroid adenoma and hyperplasia can be explained by very high HGF production by tumor cells. Nevertheless, there is no decrease of HGF serum levels after the parathyroidectomy. That may be the result of the extratumoral production of this cytokine. Also TGFbeta1 and IGF-I serum levels indicate high possibility of the extratumoral production of these cytokines. Higher postoperative IGF-I serum levels (but not significantly) in parathyroid secondary hyperplasia are in accordance with its bone production.
肝细胞生长因子（HGF）、转化生长因子β1（TGFβ1）和胰岛素样生长因子I（IGF-I）是参与甲状旁腺肿瘤形成和生长的细胞因子。我们试图确定甲状旁腺肿瘤细胞产生这些细胞因子的过程中是否存在变化及相互关系。
我们测定了16例甲状旁腺腺瘤患者和8例甲状旁腺继发性增生患者在甲状旁腺切除术前及术后外周血血清中HGF、TGFβ1和IGF-I的浓度。将结果与健康人的血清水平进行比较。
甲状旁腺腺瘤患者和继发性增生患者术前及术后的血清HGF水平均显著高于健康人。与健康人群及甲状旁腺继发性增生术前相比，甲状旁腺腺瘤患者术前及术后的血清TGFβ1水平以及甲状旁腺继发性增生患者术后的血清TGFβ1水平均较高。所有研究患者组之间的IGF-I血清水平无显著差异。
甲状旁腺肿瘤细胞生长因子产生的变化通过其在外周血中的浓度得以体现。甲状旁腺腺瘤和增生患者血清HGF水平升高可由肿瘤细胞大量产生HGF来解释。然而，甲状旁腺切除术后血清HGF水平并未降低。这可能是该细胞因子在肿瘤外产生的结果。同样，TGFβ1和IGF-I血清水平也表明这些细胞因子在肿瘤外产生的可能性很高。甲状旁腺继发性增生患者术后较高的IGF-I血清水平（但无显著差异）与其在骨骼中的产生情况相符。
Zotero 插件