土耳其人群中δ-氨基乙酰丙酸脱水酶（ALAD）基因多态性的分子分析。
Molecular analysis of delta-aminolevulinic acid dehydratase (ALAD) gene polymorphism in a Turkish population.
作者信息
Süzen Halit Sinan, Duydu Yalçin, Aydin Ahmet
机构信息
Department of Toxicology, Faculty of Pharmacy, University of Ankara, Tandogan 06100, Ankara, Turkey.
出版信息
Biochem Genet. 2004 Dec;42(11-12):461-7. doi: 10.1023/b:bigi.0000043988.79625.89.
delta-Aminolevulinic acid dehydratase (ALAD) is a cytosolic enzyme in the heme biosynthetic pathway. ALAD is a polymorphic enzyme showing marked ethnic group differences. In this study, ALAD polymorphism is studied in a Turkish population. Genomic DNA extracted from 230 individuals and polymerase chain reaction (PCR) coupled with the restriction fragment length polymorphism (RFLP) technique were used to identify variants. The frequencies of the alleles ALAD1 and ALAD2 in Turkey were 0.887 and 0.113, respectively. This study provides the first analysis of the allele frequency distribution of the ALAD gene in a Turkish population. The results are compared with other world populations.
δ-氨基乙酰丙酸脱水酶（ALAD）是血红素生物合成途径中的一种胞质酶。ALAD是一种多态性酶，存在显著的种族差异。在本研究中，对土耳其人群中的ALAD多态性进行了研究。从230名个体中提取基因组DNA，并使用聚合酶链反应（PCR）结合限制性片段长度多态性（RFLP）技术来鉴定变体。土耳其人群中ALAD1和ALAD2等位基因的频率分别为0.887和0.113。本研究首次分析了土耳其人群中ALAD基因的等位基因频率分布。并将结果与其他世界人群进行了比较。
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