细胞外ATP和UTP对大鼠离体肝细胞具有相似的作用。
Extracellular ATP and UTP exert similar effects on rat isolated hepatocytes.
作者信息
Keppens S, Vandekerckhove A, De Wulf H
机构信息
Afdeling Biochemie, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Belgium.
出版信息
Br J Pharmacol. 1992 Feb;105(2):475-9. doi: 10.1111/j.1476-5381.1992.tb14278.x.
Abstract
- Extracellular UTP and ATP show obvious similarities in their control of several metabolic functions of rat isolated hepatocytes. 2. They have a similar time-course and concentration-dependency for the activation of glycogen phosphorylase, the generation of inositol trisphosphate (IP3), the inhibition of glycogen synthase and the lowering of adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels. 3. There is a similar synergism of the nucleotides with glucagon in activating phosphorylase. 4. They undergo a similar inhibition by phorbol myristic acid of their glycogenolytic effect. 5. The ATP and UTP effect on IP3 levels are not additive. 6. It is tentatively concluded that UTP and ATP use a common receptor.
摘要
- 细胞外的尿苷三磷酸（UTP）和三磷酸腺苷（ATP）在对大鼠离体肝细胞的几种代谢功能的调控方面表现出明显的相似性。2. 它们在激活糖原磷酸化酶、生成肌醇三磷酸（IP3）、抑制糖原合酶以及降低腺苷3':5'-环磷酸（环磷酸腺苷）水平方面具有相似的时间进程和浓度依赖性。3. 在激活磷酸化酶方面，核苷酸与胰高血糖素存在相似的协同作用。4. 佛波醇肉豆蔻酸酯对它们的糖原分解作用具有相似的抑制作用。5. ATP和UTP对IP3水平的影响并非相加性的。6. 初步得出结论，UTP和ATP使用共同的受体。
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