金黄色葡萄球菌“超级细菌”。
The Staphylococcus aureus "superbug".
作者信息
Foster Timothy J
机构信息
Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland.
出版信息
J Clin Invest. 2004 Dec;114(12):1693-6. doi: 10.1172/JCI23825.
Abstract
There has been some debate about the disease-invoking potential of Staphylococcus aureus strains and whether invasive disease is associated with particularly virulent genotypes, or "superbugs." A study in this issue of the JCI describes the genotyping of a large collection of nonclinical, commensal S. aureus strains from healthy individuals in a Dutch population. Extensive study of their genetic relatedness by amplified restriction fragment typing and comparison with strains that are associated with different types of infections revealed that the S. aureus population is clonal and that some strains have enhanced virulence. This is discussed in the context of growing interest in the mechanisms of bacterial colonization, antibiotic resistance, and novel vaccines.
摘要
关于金黄色葡萄球菌菌株引发疾病的可能性，以及侵袭性疾病是否与特别具有毒力的基因型或“超级细菌”相关，一直存在一些争论。本期《临床研究杂志》上的一项研究描述了对荷兰人群中大量来自健康个体的非临床共生金黄色葡萄球菌菌株进行基因分型的情况。通过扩增限制性片段分型对它们的遗传相关性进行广泛研究，并与与不同类型感染相关的菌株进行比较，结果显示金黄色葡萄球菌群体是克隆性的，并且一些菌株具有增强的毒力。本文将在人们对细菌定植机制、抗生素耐药性和新型疫苗兴趣日益浓厚的背景下对此进行讨论。
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