Burgess Helen J, Savic Natasha, Sletten Tracey, Roach Gregory, Gilbert Saul S, Dawson Drew
Biological Rhythms Research Laboratory, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.
Behav Sleep Med. 2003;1(2):102-14. doi: 10.1207/S15402010BSM0102_3.
The endogenous melatonin onset in dim light (DLMO) is a marker of circadian phase that can be used to appropriately time the administration of bright light or exogenous melatonin in order to elicit a desired phase shift. Determining an individual's circadian phase can be costly and time-consuming. We examined the relationship between the DLMO and sleep times in 16 young healthy individuals who slept at their habitual times for a week. The DLMO occurred about 2 hours before bedtime and 14 hours after wake. Wake time and midpoint of sleep were significantly associated with the DLMO (r = 0.77, r = 0.68 respectively), but bedtime was not (r = 0.36). The possibility of predicting young healthy normally entrained people's DLMOs from their sleep times is discussed.
暗光下内源性褪黑素起始时间(DLMO)是昼夜节律相位的一个标志物,可用于确定给予强光或外源性褪黑素的合适时间,以引发期望的相位偏移。确定个体的昼夜节律相位可能成本高昂且耗时。我们研究了16名年轻健康个体的DLMO与睡眠时间之间的关系,这些个体按习惯时间睡眠一周。DLMO出现在就寝时间前约2小时和醒来后14小时。起床时间和睡眠中点与DLMO显著相关(分别为r = 0.77,r = 0.68),但就寝时间与DLMO无显著相关性(r = 0.36)。本文讨论了根据睡眠时间预测年轻健康正常节律人群DLMO的可能性。