新型4,5-二芳基咪唑啉作为强效P2X7受体拮抗剂的合成与构效关系研究
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
作者信息
Merriman Gregory H, Ma Liang, Shum Patrick, McGarry Daniel, Volz Frank, Sabol Jeffrey S, Gross Alexandre, Zhao Zhicheng, Rampe David, Wang Lin, Wirtz-Brugger Friederike, Harris Bruce A, Macdonald Douglas
机构信息
Aventis Inc., 1041 Route 202-206, Bridgewater, New Jersey, NJ 08807-0800, USA.
出版信息
Bioorg Med Chem Lett. 2005 Jan 17;15(2):435-8. doi: 10.1016/j.bmcl.2004.10.052.
PMID:15603968
Abstract
A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described.
摘要
使用高通量固相和微波技术制备了一系列4,5-二芳基咪唑啉文库。对这些化合物作为P2X(7)拮抗剂进行了评估，并描述了它们的构效关系。
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