Huang Yun-sheng, Xie Wei, Chen Bao-tian
Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Dec;24(12):1379-81.
To study the effect of saikosaponins on the electroencephalogram (EEG) of epileptic rats to evaluate its therapeutic effect against epilepsies.
Sixty 8-week-old healthy SD rats were randomized into normal control group (A), epileptic model group (B), lamotrigine group (C), and 3 saikosaponin groups of small, moderate and high doses (D, E, and F groups, respectively), with 10 rats in each group. Penicillin was used to induce epilepsy in the latter 5 groups, and the EEG and onset of epileptic seizures were observed in each group.
In group B, the EEG contained obvious epileptic discharges, which were not found in that in group A. After treatment with saikosaponins and lamotrignie, the EEG of group C and F became normal, whereas the EEG in group D still contained epileptic discharges at a low level, and that in group E was basically normal. The EEGs of group C, D, E, and F were significantly different from that in group B (P<0.001).
Saikosaponins can obviously alleviate the severity of epileptic seizure in epileptic rats.
研究柴胡皂苷对癫痫大鼠脑电图（EEG）的影响，以评估其抗癫痫的治疗效果。
将60只8周龄健康SD大鼠随机分为正常对照组（A组）、癫痫模型组（B组）、拉莫三嗪组（C组）和3个柴胡皂苷小、中、高剂量组（分别为D、E、F组），每组10只。后5组用青霉素诱导癫痫，观察每组的脑电图及癫痫发作情况。
B组脑电图有明显癫痫放电，A组未发现。经柴胡皂苷和拉莫三嗪治疗后，C组和F组脑电图恢复正常，而D组脑电图仍有低水平癫痫放电，E组基本正常。C、D、E、F组脑电图与B组相比差异有统计学意义（P<0.001）。
柴胡皂苷能明显减轻癫痫大鼠癫痫发作的严重程度。
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