Retter Ida, Althaus Hans Helmar, Münch Richard, Müller Werner
Department of Experimental Immunology, German Research Centre for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D671-4. doi: 10.1093/nar/gki088.
The database VBASE2 provides germ-line sequences of human and mouse immunoglobulin variable (V) genes. It acts as an interconnecting platform between several existing self-contained data systems: VBASE2 integrates genome sequence data and links to the V genes in the Ensembl Genome Browser. For a single V gene sequence, all references to the EMBL nucleotide sequence database are provided, including references for V(D)J rearrangements. Furthermore, cross-references to the VBASE database, the IMGT database and the Kabat database are available. A DAS server allows the display of VBASE2 V genes within the Ensembl Genome Browser. VBASE2 can be accessed either by a web-based text query or by a sequence similarity search with the DNAPLOT software. VBASE2 is available at http://www.vbase2.org, and the DAS server is located at http://www.dnaplot.com/das.
数据库VBASE2提供人类和小鼠免疫球蛋白可变（V）基因的种系序列。它充当几个现有的独立数据系统之间的互连平台：VBASE2整合基因组序列数据并链接到Ensembl基因组浏览器中的V基因。对于单个V基因序列，提供了对EMBL核苷酸序列数据库的所有引用，包括V（D）J重排的引用。此外，还提供了对VBASE数据库、IMGT数据库和Kabat数据库的交叉引用。一个DAS服务器允许在Ensembl基因组浏览器中显示VBASE2 V基因。可以通过基于网络的文本查询或使用DNAPLOT软件进行序列相似性搜索来访问VBASE2。可通过http://www.vbase2.org访问VBASE2，DAS服务器位于http://www.dnaplot.com/das。
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