在一名骨髓移植受者中，膀胱内灌注西多福韦治疗由11型腺病毒引起的出血性膀胱炎。
Intravesical instillation of cidofovir in the treatment of hemorrhagic cystitis caused by adenovirus type 11 in a bone marrow transplant recipient.
作者信息
Fanourgiakis Panagiotis, Georgala Aspasia, Vekemans Marc, Triffet Agnes, De Bruyn Jean-Marc, Duchateau Valerie, Martiat Philippe, De Clercq Erik, Snoeck Robert, Wollants Elke, Rector Annabel, Van Ranst Marc, Aoun Michael
机构信息
Infectious Disease Department, Institute Jules Bordet, Brussels, Belgium.
出版信息
Clin Infect Dis. 2005 Jan 1;40(1):199-201. doi: 10.1086/426594. Epub 2004 Dec 6.
Hemorrhagic cystitis that occurs late after bone marrow transplantation (BMT) in BMT recipients is often associated with adenovirus or polyomavirus BK infections. Intravesical instillation of cidofovir in a BMT recipient with intractable hemorrhagic cystitis resulted in clinical improvement. Local cidofovir therapy for viral hemorrhagic cystitis could be an alternative to intravenous administration of cidofovir.
骨髓移植（BMT）受者在骨髓移植后晚期发生的出血性膀胱炎通常与腺病毒或多瘤病毒BK感染有关。对一名患有顽固性出血性膀胱炎的BMT受者进行膀胱内灌注西多福韦后，临床症状有所改善。局部应用西多福韦治疗病毒性出血性膀胱炎可能是静脉注射西多福韦的一种替代方法。
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