用于生成动态组合库的可逆狄尔斯-阿尔德反应。
Reversible Diels-Alder reactions for the generation of dynamic combinatorial libraries.
作者信息
Boul Peter J, Reutenauer Philippe, Lehn Jean-Marie
机构信息
Laboratoire de Chimie Supramoléculaire, ISIS, Université Louis Pasteur, 8, allée Gaspard Monge, BP70028, F67083 Strasbourg, Cedex, France.
出版信息
Org Lett. 2005 Jan 6;7(1):15-8. doi: 10.1021/ol048065k.
Condensation reactions between various dienes and dienophiles have been screened for reversibility. Functionalized fulvenes, bearing in particular biological groups, and cyanolefins have been found to react rapidly and reversibly, in the temperature range from -10 to +50 degrees C. These results pave the way for the development of dynamic combinatorial libraries based on reversible Diels-Alder chemistry.
已对各种双烯体和亲双烯体之间的缩合反应进行了可逆性筛选。已发现带有特定生物基团的官能化富烯和氰基烯烃在-10至+50摄氏度的温度范围内能快速且可逆地反应。这些结果为基于可逆狄尔斯-阿尔德化学的动态组合库的开发铺平了道路。
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