患有攻击型和非攻击型注意力缺陷多动障碍（ADHD）儿童对哌甲酯的反应：基于症状实验室测量的差异
Methylphenidate response in aggressive and nonaggressive ADHD children: distinctions on laboratory measures of symptoms.
作者信息
Matier K, Halperin J M, Sharma V, Newcorn J H, Sathaye N
机构信息
Department of Psychology, City University of New York, Flushing 11367.
出版信息
J Am Acad Child Adolesc Psychiatry. 1992 Mar;31(2):219-25. doi: 10.1097/00004583-199203000-00007.
Response to a single, 5-mg dose of methylphenidate was compared in aggressive and nonaggressive attention-deficit hyperactivity disorder (ADHD) children using objective measures of inattention, impulsivity, and activity level. After medication, both ADHD groups had a significant decrease in inattention, whereas impulsivity remained unchanged. Activity level decreased only in the nonaggressive ADHD group. Unmedicated normal controls showed no change on any measure. These results support the hypothesis that aggressive and nonaggressive ADHD children have somewhat different underlying determinants for some of their symptoms. In addition, they suggest that inattention, impulsivity, and overactivity may be mediated by partially distinct neural mechanisms.
使用注意力不集中、冲动和活动水平的客观测量方法，对患有攻击型和非攻击型注意力缺陷多动障碍（ADHD）的儿童服用单次5毫克剂量哌甲酯后的反应进行了比较。用药后，两个ADHD组的注意力不集中情况均有显著改善，而冲动性没有变化。活动水平仅在非攻击型ADHD组中有所下降。未用药的正常对照组在任何测量指标上均无变化。这些结果支持了这样的假设，即攻击型和非攻击型ADHD儿童某些症状的潜在决定因素有所不同。此外，这表明注意力不集中、冲动和多动可能由部分不同的神经机制介导。
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