Lochner Christine, Seedat Soraya, du Toit Pieter L, Nel Daniel G, Niehaus Dana J H, Sandler Robin, Stein Dan J
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa.
BMC Psychiatry. 2005 Jan 13;5:2. doi: 10.1186/1471-244X-5-2.
Similarities between obsessive-compulsive disorder (OCD) and trichotillomania (TTM) have been widely recognized. Nevertheless, there is evidence of important differences between these two disorders. Some authors have conceptualized the disorders as lying on an OCD spectrum of conditions.
Two hundred and seventy eight OCD patients (n = 278: 148 male; 130 female) and 54 TTM patients (n = 54; 5 male; 49 female) of all ages were interviewed. Female patients were compared on select demographic and clinical variables, including comorbid axis I and II disorders, and temperament/character profiles.
OCD patients reported significantly more lifetime disability, but fewer TTM patients reported response to treatment. OCD patients reported higher comorbidity, more harm avoidance and less novelty seeking, more maladaptive beliefs, and more sexual abuse. OCD and TTM symptoms were equally likely to worsen during menstruation, but OCD onset or worsening was more likely associated with pregnancy/puerperium.
These findings support previous work demonstrating significant differences between OCD and TTM. The classification of TTM as an impulse control disorder is also problematic, and TTM may have more in common with conditions characterized by stereotypical self-injurious symptoms, such as skin-picking. Differences between OCD and TTM may reflect differences in underlying psychobiology, and may necessitate contrasting treatment approaches.
强迫症(OCD)与拔毛癖(TTM)之间的相似性已得到广泛认可。然而,有证据表明这两种疾病之间存在重要差异。一些作者已将这些疾病概念化为处于强迫症谱系之中。
对278例各年龄段的强迫症患者(n = 278:148例男性;130例女性)和54例拔毛癖患者(n = 54;5例男性;49例女性)进行了访谈。对女性患者在选定的人口统计学和临床变量方面进行了比较,包括共病的轴I和轴II障碍以及气质/性格特征。
强迫症患者报告的终生残疾显著更多,但拔毛癖患者报告对治疗有反应的较少。强迫症患者报告的共病率更高,回避伤害更多,寻求新奇更少,适应不良信念更多,性虐待更多。强迫症和拔毛癖症状在月经期间同样可能加重,但强迫症的发病或加重更可能与怀孕/产褥期有关。
这些发现支持了先前的研究工作,表明强迫症和拔毛癖之间存在显著差异。将拔毛癖归类为冲动控制障碍也存在问题,拔毛癖可能与以刻板的自我伤害症状为特征的疾病(如皮肤搔抓症)有更多共同之处。强迫症和拔毛癖之间的差异可能反映了潜在心理生物学方面的差异,可能需要不同的治疗方法。