尺寸为何重要：静纤毛长度的动态调节

When size matters: the dynamic regulation of stereocilia lengths.

作者信息

Lin Harrison W, Schneider Mark E, Kachar Bechara

机构信息

Section on Structural Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892-8027, USA.

出版信息

Curr Opin Cell Biol. 2005 Feb;17(1):55-61. doi: 10.1016/j.ceb.2004.12.005.

DOI:10.1016/j.ceb.2004.12.005

PMID:15661519

Abstract

Stereocilia, the mechanosensitive protrusions in hair cells, are organized into rows of graded heights forming precisely uniform staircase patterns. The actin turnover process in stereocilia follows a treadmill model in which the rate of treadmilling is scaled to the stereocilium's length. Myosin XVa, which is present at the site of actin polymerization at concentrations proportional to the length of the actin filament bundles, plays a combined role with the treadmill machinery in regulating the steady state length of these actin protrusions, together with other myosins localized alongside the actin bundles.

摘要

静纤毛是毛细胞中的机械敏感突起，它们被组织成高度渐变的排，形成精确均匀的阶梯模式。静纤毛中的肌动蛋白周转过程遵循一种踏车模型，其中踏车速率与静纤毛的长度成比例。肌球蛋白XVa存在于肌动蛋白聚合位点，其浓度与肌动蛋白丝束的长度成比例，它与踏车机制共同作用，与沿着肌动蛋白束定位的其他肌球蛋白一起调节这些肌动蛋白突起的稳态长度。