癌细胞侵袭的机制。

Mechanisms of cancer cell invasion.

作者信息

Sahai Erik

机构信息

Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.

出版信息

Curr Opin Genet Dev. 2005 Feb;15(1):87-96. doi: 10.1016/j.gde.2004.12.002.

DOI:10.1016/j.gde.2004.12.002

PMID:15661538

Abstract

The movement of cancer cells into tissue surrounding the tumour and the vasculature is the first step in the spread of metastatic cancers. Recent advances in imaging, the use of 3D model systems and the application of microarray technologies have yielded new insights into these processes. This work has challenged our views about what causes cancer cells to become motile in the first place, and has demonstrated that cancer cells can move in many different ways.

摘要

癌细胞向肿瘤周围组织和脉管系统的移动是转移性癌症扩散的第一步。成像技术的最新进展、3D模型系统的使用以及微阵列技术的应用，为这些过程带来了新的见解。这项工作挑战了我们对于癌细胞最初如何变得具有运动性的看法，并表明癌细胞可以通过多种不同方式移动。