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[庆大霉素所致的耳蜗-前庭耳毒性。1例报告及文献复习]

[Cochlear-vestibular ototoxicity by gentamicin. Report of a case and literature review].

作者信息

Pino Rivero V, Marcos García M, Keituqwa Yáñez T, González Palomino A, Trinidad Ruiz G, Pardo Romero G, Blasco Huelva A

机构信息

Facultativo Especialista de Otorrinolaringologia. Hospital Infanta Cristina.

出版信息

An Otorrinolaringol Ibero Am. 2004;31(6):531-7.

Abstract

Gentamicin is an antibiotic member of the aminoglycosides family with well known potential to cause permanent ototoxicity by damaging more likely the cochlea vestibular system. We are reporting the clinical case of a 48 year-old female who was treated with such IV drug because of abdominal surgery. She had no otologic past history, and was complaining of tinnitus, periferical vertigo and progressive bilateral neurosensorial hearing loss, it est, cochlear-vestibular symptoms. After the withdrawol of gentamicin, the vestibular pathologic symptoms but not the hearing loss had improved, docummented by the persistance of the audiometric decay in the acute frequencies. Prevention is the best way to avoid iatrogenic lesions with thesse climps.

摘要

庆大霉素是氨基糖苷类抗生素家族的一员,众所周知,它有通过更可能损害耳蜗前庭系统而导致永久性耳毒性的潜在风险。我们报告了一名48岁女性的临床病例,该女性因腹部手术接受了这种静脉注射药物治疗。她既往无耳科病史,主诉耳鸣、周围性眩晕和进行性双侧感音神经性听力损失,即耳蜗前庭症状。停用庆大霉素后,前庭病理症状有所改善,但听力损失未改善,这通过急性频率听力减退的持续存在得到证实。预防是避免这些医源性损伤的最佳方法。

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