阿尔茨海默病β-淀粉样蛋白前体的细胞质结构域：功能、蛋白水解调节及其对药物开发的意义。

Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development.

作者信息

Kerr Megan L, Small David H

机构信息

Laboratory of Molecular Neurobiology, Department of Biochemistry and Molecular Biology, and Monash University Centre for Brain and Behaviour, Monash University, Victoria, Australia.

出版信息

J Neurosci Res. 2005 Apr 15;80(2):151-9. doi: 10.1002/jnr.20408.

DOI:10.1002/jnr.20408

PMID:15672415

Abstract

The beta-amyloid protein precursor (APP) has been extensively studied for its role in amyloid production and the pathogenesis of Alzheimer's disease (AD). However, little is known about the normal function of APP and its biological interactions. In this Mini-Review, the role of the cytoplasmic domain of APP in APP trafficking and proteolysis is described. These studies suggest that proteins that bind to the cytoplasmic domain may be important targets for drug development in AD.

摘要

β-淀粉样蛋白前体（APP）因其在淀粉样蛋白生成及阿尔茨海默病（AD）发病机制中的作用而受到广泛研究。然而，对于APP的正常功能及其生物学相互作用却知之甚少。在本综述中，描述了APP胞质结构域在APP运输和蛋白水解中的作用。这些研究表明，与胞质结构域结合的蛋白质可能是AD药物开发的重要靶点。