在蝙蝠中发现一种新型冠状病毒。
Identification of a novel coronavirus in bats.
作者信息
Poon L L M, Chu D K W, Chan K H, Wong O K, Ellis T M, Leung Y H C, Lau S K P, Woo P C Y, Suen K Y, Yuen K Y, Guan Y, Peiris J S M
机构信息
Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, Special Administrative Region, People's Republic of China.
出版信息
J Virol. 2005 Feb;79(4):2001-9. doi: 10.1128/JVI.79.4.2001-2009.2005.
Exotic wildlife can act as reservoirs of diseases that are endemic in the area or can be the source of new emerging diseases through interspecies transmission. The recent emergence of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) highlights the importance of virus surveillance in wild animals. Here, we report the identification of a novel bat coronavirus through surveillance of coronaviruses in wildlife. Analyses of the RNA sequence from the ORF1b and S-gene regions indicated that the virus is a group 1 coronavirus. The virus was detected in fecal and respiratory samples from three bat species (Miniopterus spp.). In particular, 63% (12 of 19) of fecal samples from Miniopterus pusillus were positive for the virus. These findings suggest that this virus might be commonly circulating in M. pusillus in Hong Kong.
外来野生动物可能是该地区地方病的宿主，也可能通过种间传播成为新出现疾病的源头。严重急性呼吸综合征相关冠状病毒（SARS-CoV）最近的出现凸显了对野生动物进行病毒监测的重要性。在此，我们报告通过对野生动物中的冠状病毒进行监测而鉴定出一种新型蝙蝠冠状病毒。对来自开放阅读框1b（ORF1b）和刺突蛋白（S）基因区域的RNA序列分析表明，该病毒属于第1组冠状病毒。在三种蝙蝠物种（长翼蝠属）的粪便和呼吸道样本中检测到了该病毒。特别是，来自普通长翼蝠的粪便样本中有63%（19份中的12份）对该病毒呈阳性。这些发现表明，这种病毒可能在香港的普通长翼蝠中普遍传播。
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