来自东方菝葜的对映-海松烷型二萜类化合物

ent-pimarane-type diterpenoids from Siegesbeckia orientalis L.

作者信息

Giang Phan Minh, Son Phan Tong, Otsuka Hideaki

机构信息

Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, Vietnam.

出版信息

Chem Pharm Bull (Tokyo). 2005 Feb;53(2):232-4. doi: 10.1248/cpb.53.232.

DOI:10.1248/cpb.53.232

PMID:15684525

Abstract

A new ent-pimarane glucoside, named hythiemoside B (4), was isolated from the aerial part of Siegesbecikia orientalis L. (Asteraceae) together with four known ent-pimarane-type diterpenoids: darutigenol (1), darutoside (2), hythiemoside A (3), and ent-(15R),16,19-trihydroxypimar-8(14)-ene 19-O-beta-D-glucopyranoside (5). The structure of the new compound was elucidated by spectroscopic analyses and chemical transformation. The NMR data of compounds 1 (1H-) and 5 (1H- and 13C-) were also compiled in this study on the basis of 2D experiments.

摘要

从东方豨莶（菊科）地上部分分离得到一种新的对映-海松烷型糖苷，命名为希替莫苷B（4），以及四种已知的对映-海松烷型二萜类化合物：达鲁替醇（1）、达鲁糖苷（2）、希替莫苷A（3）和对映-（15R），16，19-三羟基海松-8（14）-烯19-O-β-D-吡喃葡萄糖苷（5）。通过光谱分析和化学转化确定了新化合物的结构。本研究还基于二维实验汇编了化合物1（1H-）和5（1H-和13C-）的核磁共振数据。