新型微管/微管蛋白靶向抗癌药物及新型化疗策略。
New microtubule/tubulin-targeted anticancer drugs and novel chemotherapeutic strategies.
作者信息
Wilson L, Jordan M A
机构信息
Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
出版信息
J Chemother. 2004 Nov;16 Suppl 4:83-5. doi: 10.1179/joc.2004.16.Supplement-1.83.
The clinical success of the taxanes and the vinca alkaloids has sparked a major search for new drugs that perturb mitotic spindle microtubule dynamics and function, yielding a large number of promising compounds. A potential valuable strategy would be to use core microtubule-targeted drugs along with novel targeted drug therapies as they are developed, where the antitumor activity of a targeted drug can be combined with the power of low dose microtubule-targeted therapy. The goal of such combination therapy is to achieve high efficacy, reduced toxicity, and reduced emergence of drug resistance.
紫杉烷类和长春花生物碱的临床成功引发了对扰乱有丝分裂纺锤体微管动力学和功能的新药的大规模探索，从而产生了大量有前景的化合物。一种潜在的有价值策略是在开发新型靶向药物疗法时，将核心微管靶向药物与之联合使用，这样靶向药物的抗肿瘤活性就可以与低剂量微管靶向疗法的功效相结合。这种联合疗法的目标是实现高疗效、降低毒性以及减少耐药性的出现。
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