4-(4-氨基苯基)吗啉席夫碱作为潜在抗菌剂的合成。
Synthesis of Schiff bases of 4-(4-aminophenyl)-morpholine as potential antimicrobial agents.
作者信息
Panneerselvam Perumal, Nair Rajasree R, Vijayalakshmi Gudaparthi, Subramanian Ekambaram Harihara, Sridhar Seshaiah Krishnan
机构信息
Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy, Old Mahabalipuram Road, Thorapakkam Chennai 600096, Tamilnadu, India.
出版信息
Eur J Med Chem. 2005 Feb;40(2):225-9. doi: 10.1016/j.ejmech.2004.09.003.
In the present study, a novel series of Schiff bases of 4-(4-aminophenyl)-morpholine were synthesised and characterised by IR, 1H-NMR, 13C-NMR, Mass spectral and elemental analysis. The compounds were screened for antibacterial (Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Bacillus cereus (ATCC 11778), Micrococcus luteus (ATCC 4678), and Escherichia coli (ATCC 25922)) and antifungal (Candida albicans (ATCC 2091) and Aspergillus niger (ATCC 9029)) activities. The minimum inhibitory concentrations of the compounds were also ascertained by agar streak dilution method. 4-(4-(4-Hydroxy-benzylidene-imino)phenyl)-morpholine (7) was found to be the most potent antimicrobial activity with MIC of 25, 19, 21, 16, 29, 20 and 40 microg/ml against S. aureus, S. epidermidis, B. cereus, M. luteus, E. coli, C. albicans and A. niger, respectively. All the other compounds exhibited moderate activity against the bacterial and fungal organisms tested.
在本研究中，合成了一系列新型的4-(4-氨基苯基)-吗啉席夫碱，并通过红外光谱、1H-核磁共振、13C-核磁共振、质谱和元素分析对其进行了表征。对这些化合物进行了抗菌（金黄色葡萄球菌（ATCC 9144）、表皮葡萄球菌（ATCC 155）、蜡样芽孢杆菌（ATCC 11778）、藤黄微球菌（ATCC 4678）和大肠杆菌（ATCC 25922））和抗真菌（白色念珠菌（ATCC 2091）和黑曲霉（ATCC 9029））活性筛选。还通过琼脂划线稀释法确定了这些化合物的最低抑菌浓度。发现4-(4-(4-羟基-亚苄基-亚氨基)苯基)-吗啉（7）具有最强的抗菌活性，对金黄色葡萄球菌、表皮葡萄球菌、蜡样芽孢杆菌、藤黄微球菌、大肠杆菌、白色念珠菌和黑曲霉的最低抑菌浓度分别为25、19、21、16、29、20和40微克/毫升。所有其他化合物对所测试的细菌和真菌均表现出中等活性。
Zotero 插件