Zijlstra T R, van de Laar M A F J, Bernelot Moens H J, Taal E, Zakraoui L, Rasker J J
Department of Rheumatology, Medisch Spectrum Twente Hospital, Enschede, The Netherlands.
Rheumatology (Oxford). 2005 Apr;44(4):539-46. doi: 10.1093/rheumatology/keh537. Epub 2005 Feb 3.
To study the effect of a combination of thalassotherapy, exercise and patient education in people with fibromyalgia.
Patients with fibromyalgia, selected from a rheumatology out-patient department and from members of the Dutch fibromyalgia patient association, were pre-randomized to receive either 2(1/2) weeks of treatment in a Tunisian spa resort, including thalassotherapy, supervised exercise and group education (active treatment) or treatment as usual (control treatment). Primary outcome measure was health-related quality of life, measured with the RAND-36 questionnaire. Secondary measures included the Fibromyalgia Impact Questionnaire, the McGill Pain Questionnaire, the Beck Depression Inventory, tender point score and a 6-min treadmill walk test.
Fifty-eight participants receiving the active treatment reported significant improvement on RAND-36 physical and mental component summary scales. For physical health, differences from the 76 controls were statistically significant after 3 months, but not after 6 and 12 months. A similar pattern of temporary improvement was seen in the self-reported secondary measures. Tender point scores and treadmill walk tests improved more after active treatment, but did not reach significant between-group differences, except for walk tests after 12 months.
A combination of thalassotherapy, exercise and patient education may temporarily improve fibromyalgia symptoms and health-related quality of life.
研究海水浴疗法、运动和患者教育相结合对纤维肌痛患者的影响。
从风湿病门诊和荷兰纤维肌痛患者协会成员中选取纤维肌痛患者,预先随机分为两组,一组在突尼斯温泉度假胜地接受为期2(1/2)周的治疗,包括海水浴疗法、有监督的运动和团体教育(积极治疗),另一组接受常规治疗(对照治疗)。主要结局指标是使用RAND-36问卷测量的健康相关生活质量。次要指标包括纤维肌痛影响问卷、麦吉尔疼痛问卷、贝克抑郁量表、压痛点评分和6分钟跑步机步行测试。
接受积极治疗的58名参与者在RAND-36身体和心理成分汇总量表上报告有显著改善。在身体健康方面,与76名对照组相比,3个月后差异有统计学意义,但6个月和12个月后无统计学意义。自我报告的次要指标也出现了类似的暂时改善模式。积极治疗后压痛点评分和跑步机步行测试改善更多,但除12个月后的步行测试外,组间差异未达到显著水平。
海水浴疗法、运动和患者教育相结合可能会暂时改善纤维肌痛症状和健康相关生活质量。