Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment.
作者信息
Schwahn B, Kameda G, Wessalowski R, Mayatepek E
机构信息
Clinic for General Pediatrics, University Children's Hospital, Moorenstrasse 5, D-40225, Düsseldorf, Germany.
出版信息
J Inherit Metab Dis. 2005;28(1):99-102. doi: 10.1007/s10545-005-5084-5.
PMID:15702411
Abstract
A hitherto healthy 7-year-old girl underwent antiproliferative and antibiotic treatment owing to the diagnosis of T-cell lymphoma and concomitant bacterial infection. She developed an encephalopathic crisis associated with metabolic acidosis, hyponatraemia and severe hyperhomocysteinaemia and 5-oxoprolinuria. Laboratory tests normalized completely after recovery. Primary defects in glutathione metabolism could be excluded.
摘要
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