Zhu Jin Liang, Madsen Kreesten M, Vestergaard Mogens, Basso Olga, Olsen Jørn
Danish Epidemiology Science Centre, University of Aarhus, Aarhus, Denmark.
Epidemiology. 2005 Mar;16(2):259-62. doi: 10.1097/01.ede.0000152526.63279.da.
There is growing evidence that advanced paternal age can be a reproductive hazard.
We studied couples and their first children using nationwide registers in Denmark between 1980 and 1996. We restricted the analysis to mother's age 20-29 years. We estimated odds ratios (ORs) of preterm (< 37 weeks gestation) and very preterm birth (< 32 weeks) as a function of paternal age using logistic regression to adjust for potential confounding variables.
The risk of preterm birth increased with paternal age, almost entirely resulting from an association for very preterm birth. Compared with fathers age 20-24 years, ORs for very preterm birth were 1.3 (age 25-29), 1.4 (age 35-39), 1.7 (age 40-44), 1.6 (age 45-49), and 2.1 (age 50+) (test for trend: P = 0.01).
Risk of very preterm birth increases among older fathers, perhaps as a result of a paternal placental effect.
越来越多的证据表明，父亲年龄偏大可能会对生殖造成危害。
我们利用丹麦全国范围的登记资料，对1980年至1996年间的夫妇及其头胎子女进行了研究。我们将分析限定在母亲年龄为20至29岁的范围内。我们使用逻辑回归来调整潜在的混杂变量，估计早产（妊娠<37周）和极早产（<32周）的比值比（OR）作为父亲年龄的函数。
早产风险随父亲年龄增加而升高，几乎完全是由极早产的关联导致的。与年龄在20至24岁的父亲相比，极早产的OR值在父亲年龄为25至29岁时为1.3，35至39岁时为1.4，40至44岁时为1.7，45至49岁时为1.6，50岁及以上时为2.1（趋势检验：P = 0.01）。
年龄较大的父亲生育极早产的风险增加，可能是由于父亲对胎盘的影响。
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