Zhan Xiao-ping, Lou Jian-guo, Jin Xiao-ying, Sun Mei, Jin Chen-yu, Xu Xi-hong, Qin Guang-ming, Xu Yan-qi, Bao Jun
The Second Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Zhongguo Zhong Yao Za Zhi. 2004 May;29(5):440-3.
To evaluate the effect of decoction for invigorating the kidney and improving blood circulation to thrombosis on rabbits blood stasis model.
Thirty rabbits were randomly divided into normal group, model group, heavy dose group, slight dose group and xue shuan ning group. Tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), fibrinogen (Fbg) and D-dimer (DD) were investigated after those rabbits had been treated. One was selected randomly from each group to observe pathological changes.
There was significant difference in t-PA, PAI, Fbg and DD between normal group and other groups (P < 0.01). Among groups of heavy dose, slight dose, xue shuan ning and model, the statistical differences were significant, as well as among groups of heavy dose, slight dose and xue shuan ning (P < 0.05). However, there was no statistical difference between heavy dose group and slight dose group (P > 0.05). The pathological changes in model group were most serious, and those in xue shuan ning were less serious. There were slight pathological change in heavy dose group and light dose group.
Models were made successfully. Heavy dose group and slight dose group have stronger effect on thrombosis than xue shuan ning group.
评价补肾活血汤对家兔血瘀模型血栓形成的影响。
将30只家兔随机分为正常组、模型组、大剂量组、小剂量组和血栓宁组。给药后检测组织型纤溶酶原激活剂（t-PA）、纤溶酶原激活剂抑制剂（PAI）、纤维蛋白原（Fbg）和D-二聚体（DD）。每组随机选取1只观察病理变化。
正常组与其他组之间t-PA、PAI、Fbg和DD差异有统计学意义（P<0.01）。大剂量组、小剂量组、血栓宁组与模型组之间差异有统计学意义，大剂量组、小剂量组与血栓宁组之间差异也有统计学意义（P<0.05）。但大剂量组与小剂量组之间差异无统计学意义（P>0.05）。模型组病理变化最严重，血栓宁组较轻，大剂量组和小剂量组有轻微病理变化。
造模成功。大剂量组和小剂量组对血栓形成的作用强于血栓宁组。
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