[P38丝裂原活化蛋白激酶在细胞周期调控中的新作用]

[The emergent role of p38 MAPKs in the regulation of cell cycle].

作者信息

Chen Yi, Miao Ze-Hong, Ding Jian

机构信息

Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai.

出版信息

Sheng Li Ke Xue Jin Zhan. 2004 Oct;35(4):315-20.

PMID:15727208

Abstract

The p38 MAPKs are members of the MAPK family. Its pathway has been traditionally associated with the stress and immune response. More recently, it has been reported that the p38 MAPKs pathway can also regulate apoptosis and some differentiation process. It can regulate cellular growth and cell cycle checkpoints in different ways depending on the cell type and the stimulus.

摘要

p38丝裂原活化蛋白激酶（MAPK）是丝裂原活化蛋白激酶家族的成员。其信号通路传统上与应激和免疫反应相关。最近，有报道称p38丝裂原活化蛋白激酶信号通路也可调节细胞凋亡和一些分化过程。它可根据细胞类型和刺激以不同方式调节细胞生长和细胞周期检查点。