Pace Maria Caterina, Aurilio Caterina, Bulletti Carlo, Iannotti Mario, Passavanti Maria Beatrice, Palagiano Antonio
Department of Anaesthetics Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.
Ann N Y Acad Sci. 2004 Dec;1034:356-63. doi: 10.1196/annals.1335.037.
Pain control during labor is a primary objective of antalgic therapy. The use of the peridural as an elective procedure for labor analgesia is now corroborated by the international scientific community. Sometimes a combined spinal-peridural procedure is used together with the intrathecal administration of opioids to also cover the first stage of labor. Unfortunately, patients and/or gynecologists often request analgesia in a late stage of labor. The aim of our study was to evaluate the possibility of using a subarachnoid block alone for labor analgesia when this is requested at a late stage, that is, in advanced labor with cervical dilation greater than 7 cm. After approval by our ethics committee and the written and informed consent of the patients, 111 women were enrolled in this study and randomly divided into two groups. The first group (Group S: 55 patients) received a subarachnoid block with 2.5 mg hyperbaric bupivacaine + 25 mug fentanyl + 1 mL 10% glucose. A pudendal nerve block with 7 mL 2% mepivacaine in each side was administered to the second group (Group P: 56 patients). In both groups, careful maternal-fetal monitoring was conducted, and pain was scored on a numerical scale from 0 to 4, 10 minutes after placement of the block (time [T] 0), at delivery (T1), and at episiorrhaphy (T2). In all patients, we recorded any side effects, the Apgar score at birth and after 5 minutes, the administration of other analgesic and/or sedative drugs, the degree of satisfaction, and the time of hospitalization after delivery. Evaluations were performed by anesthesiologists unaware of patients' treatment group. The duration of spinal analgesia was considered to be the time from injection of study drugs to the time of the patient's first request for additional analgesia. In no cases were there any side effects worthy of note, and hospitalization never exceeded 72 hours. The Apgar score was always between 7 and 10. All except one of the women in Group S were satisfied or more than satisfied with their pain management, whereas 50 women in Group P expressed only moderate satisfaction or dissatisfaction (P < 0.0001). In most patients in Group S, complete analgesia was obtained. In Group P, however, 10 minutes after placement of the pudendal nerve block, 40 patients reported no improvement in pain symptomatology during contractions and only 16 reported less painful contractions (P < 0.0001). The duration of spinal analgesia (128 +/- 38 minutes) was enough in most cases for delivery to be completed. These results suggest that low-dose bupivacaine-fentanyl spinal analgesia represents an important option for pain relief in late labor, not the least because the procedure does not upset the dynamics of delivery or alter vital parameters and is welcomed by women in labor who are still able to collaborate actively in the birth of their baby.
分娩期间的疼痛控制是镇痛治疗的主要目标。硬膜外麻醉作为分娩镇痛的一种选择性方法,目前已得到国际科学界的证实。有时会采用腰麻 - 硬膜外联合麻醉,并鞘内注射阿片类药物,以覆盖分娩的第一阶段。不幸的是,患者和/或妇科医生常常在分娩后期才要求镇痛。我们研究的目的是评估在分娩后期(即宫颈扩张大于7 cm的晚期分娩)单独使用蛛网膜下腔阻滞进行分娩镇痛的可能性。经我们的伦理委员会批准并获得患者的书面知情同意后,111名女性被纳入本研究并随机分为两组。第一组(S组:55例患者)接受2.5 mg重比重布比卡因 + 25 μg芬太尼 + 1 mL 10%葡萄糖的蛛网膜下腔阻滞。第二组(P组:56例患者)在每侧接受7 mL 2%甲哌卡因的阴部神经阻滞。两组均进行了仔细的母婴监测,并在阻滞放置后10分钟(时间[T]0)、分娩时(T1)和会阴缝合时(T2),采用0至4的数字评分法对疼痛进行评分。在所有患者中,我们记录了任何副作用、出生时和5分钟后的阿氏评分、其他镇痛和/或镇静药物的使用、满意度以及分娩后的住院时间。评估由不了解患者治疗组情况的麻醉医生进行。蛛网膜下腔镇痛的持续时间被认为是从注射研究药物到患者首次要求追加镇痛的时间。在任何情况下均未出现值得注意的副作用,住院时间从未超过72小时。阿氏评分始终在7至10之间。S组除一名女性外,所有女性对其疼痛管理感到满意或非常满意,而P组有50名女性仅表示中度满意或不满意(P < 0.0001)。在S组的大多数患者中,获得了完全镇痛。然而,在P组中,阴部神经阻滞放置后10分钟,40例患者报告宫缩时疼痛症状无改善,只有16例报告宫缩疼痛减轻(P < 0.0001)。蛛网膜下腔镇痛的持续时间(128 ± 38分钟)在大多数情况下足以完成分娩。这些结果表明,低剂量布比卡因 - 芬太尼蛛网膜下腔镇痛是晚期分娩疼痛缓解的一个重要选择,尤其是因为该方法不会打乱分娩进程或改变生命参数,并且受到仍能积极配合分娩的产妇的欢迎。