Kurtz Theodore W, Griffin Karen A, Bidani Anil K, Davisson Robin L, Hall John E
Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):e22-33. doi: 10.1161/01.ATV.0000158419.98675.d7.
In experimental animals, as in humans, techniques for measuring blood pressure (BP) have improved considerably over the past decade. In this document, we present recommendations for measuring BP in experimental animals with the goal of helping investigators select optimal methods for BP monitoring in the research laboratory. The advantages and disadvantages of various BP measurement methods are discussed and specific recommendations are provided for selecting the optimal technique depending on the study objective. Although indirect techniques that permit only sporadic measurements of BP may be suitable for some purposes, methods for directly measuring BP are generally preferred because of their ability to monitor the highly dynamic nature of BP in a comprehensive fashion. Selection of the methods to be used should ultimately be guided by the study objectives to insure that the techniques chosen are appropriate for the experimental questions being explored.
与人类一样,在过去十年中,实验动物的血压(BP)测量技术有了显著改进。在本文件中,我们提出了实验动物血压测量的建议,目的是帮助研究人员在研究实验室中选择最佳的血压监测方法。讨论了各种血压测量方法的优缺点,并根据研究目的提供了选择最佳技术的具体建议。虽然仅允许偶尔测量血压的间接技术可能适用于某些目的,但直接测量血压的方法通常更受青睐,因为它们能够全面监测血压的高度动态变化。最终应根据研究目的来指导所使用方法的选择,以确保所选技术适合正在探索的实验问题。