情绪是由化学物质决定的吗？

Is mood chemistry?

作者信息

Castrén Eero

机构信息

Neuroscience Center, University of Helsinki, Finland.

出版信息

Nat Rev Neurosci. 2005 Mar;6(3):241-6. doi: 10.1038/nrn1629.

DOI:10.1038/nrn1629

PMID:15738959

Abstract

The chemical hypothesis of depression suggests that mood disorders are caused by a chemical imbalance in the brain, which can be corrected by antidepressant drugs. However, recent evidence indicates that problems in information processing within neural networks, rather than changes in chemical balance, might underlie depression, and that antidepressant drugs induce plastic changes in neuronal connectivity, which gradually lead to improvements in neuronal information processing and recovery of mood.

摘要

抑郁症的化学假说认为，情绪障碍是由大脑中的化学失衡引起的，而抗抑郁药物可以纠正这种失衡。然而，最近的证据表明，神经网络内信息处理方面的问题，而非化学平衡的变化，可能是抑郁症的潜在原因，并且抗抑郁药物会引起神经元连接的可塑性变化，这会逐渐导致神经元信息处理的改善和情绪的恢复。