[HIV感染患者的神经精神症状及依非韦伦的作用]

[Neurospychiatric symptoms in HIV infected patients and the role of efavirenz].

作者信息

Bary M, David F, Gasnault J, Kerneis H, Linard F, Longuet P, Pelissolo A, Ravaux I

机构信息

Centre du Moulin Joly, 5, rue du Moulin-Joly, 75011 Paris, France.

出版信息

Med Mal Infect. 2004 Oct;34(10):435-49. doi: 10.1016/j.medmal.2004.04.007.

DOI:10.1016/j.medmal.2004.04.007

PMID:15747468

Abstract

Efavirenz has now become commonly used to treat HIV infection. Neuropsychiatric disorders have been reported in patients treated with efavirenz. Several factors often make it hard to determine the cause of these disorders: HIV infected patients take many different drugs, they may suffer from various organ diseases, and may also be heavily affected by problems in their everyday life. The French experts group working on neuropsychiatric side effects of efavirenz has undertaken a review of these disorders with the aim to identify: (1) semiology, (2) epidemiology in the global population, in HIV infected patients, and in patients treated with efavirenz. The expert group suggests recommendations to manage these disorders.

摘要

依法韦仑现已普遍用于治疗HIV感染。有报告称接受依法韦仑治疗的患者出现了神经精神障碍。有几个因素常常使得难以确定这些障碍的病因：HIV感染患者服用多种不同药物，他们可能患有各种器官疾病，并且还可能受到日常生活问题的严重影响。研究依法韦仑神经精神副作用的法国专家组对这些障碍进行了综述，目的是确定：(1) 症状学，(2) 全球人群、HIV感染患者以及接受依法韦仑治疗患者中的流行病学情况。专家组提出了管理这些障碍的建议。