组织肾素-血管紧张素系统的分子证据：聚焦于脑
Molecular evidence of tissue renin-angiotensin systems: a focus on the brain.
作者信息
Sakai Koji, Sigmund Curt D
机构信息
Department of Internal Medicine and Physiology, 3181B Medical Education and Biomedical Research Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
出版信息
Curr Hypertens Rep. 2005 Apr;7(2):135-40. doi: 10.1007/s11906-005-0088-y.
Abstract
Hypertension remains one of the largest human health problems, because hypertensive patients carry increased risk for ischemic heart disease, stroke, atherosclerosis, and renal failure. The renin-angiotensin system (RAS) has been intensively investigated for more than 100 years because it is a powerful regulator of blood pressure, and the antihypertensive benefits of RAS inhibitors are very clear. Despite a wealth of clinical and basic studies, the precise mechanisms by which the RAS regulates blood pressure remains incomplete. In this chapter, we review data demonstrating the existence and function of intrinsic tissue RAS, with a primary focus on the brain.
摘要
高血压仍然是最大的人类健康问题之一，因为高血压患者患缺血性心脏病、中风、动脉粥样硬化和肾衰竭的风险增加。肾素-血管紧张素系统（RAS）已经被深入研究了100多年，因为它是血压的强力调节因子，而且RAS抑制剂的降压益处非常明确。尽管有大量的临床和基础研究，但RAS调节血压的确切机制仍不完整。在本章中，我们回顾了证明内源性组织RAS的存在和功能的数据，主要聚焦于脑。
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