Herrmann J, Funk J
Augenklinik, Albert-Ludwigs-Universität, Freiburg.
Ophthalmologe. 2005 Aug;102(8):778-82. doi: 10.1007/s00347-005-1192-8.
Primary open-angle glaucoma is characterized by a loss of retinal nerve fibres. The aim of our present study was to evaluate the diagnostic value of retinal nerve fibre layer (RNFL) photography as a routine examination for the early diagnosis of glaucomatous damage.
Between 1991 and 2000 we monitored 96 patients with ocular hypertension in a prospective study. RNFL photography was performed in 91 subjects. These photos were evaluated by two independent observers.
The mean image quality of the photos was mediocre. The correlation coefficient for the intraindividual reproducibility (image quality) was 0.713-0.863 (Kendall's coefficient). For the interindividual reproducibility the correlation coefficient was 0.541-0.581 (Somers' coefficient). Regarding the evaluation "RNFL defect yes/no", the correlations were better but there was a discrepancy between the observers.
Quality, reproducibility and prognostic value of RNFL photography were disappointing. Although RNFL photography may be convincing and informative in several situations, it is not efficient as a routine technique for the early diagnosis of RNFL damage in glaucoma patients.
原发性开角型青光眼的特征是视网膜神经纤维丧失。我们当前研究的目的是评估视网膜神经纤维层(RNFL)摄影作为青光眼性损害早期诊断的常规检查的诊断价值。
在1991年至2000年期间,我们在一项前瞻性研究中监测了96例高眼压症患者。对91名受试者进行了RNFL摄影。这些照片由两名独立观察者进行评估。
照片的平均图像质量一般。个体内再现性(图像质量)的相关系数为0.713 - 0.863(肯德尔系数)。个体间再现性的相关系数为0.541 - 0.581(萨默斯系数)。关于“RNFL缺陷是/否”的评估,相关性较好,但观察者之间存在差异。
RNFL摄影的质量、再现性和预后价值令人失望。尽管RNFL摄影在某些情况下可能具有说服力且信息丰富,但作为青光眼患者RNFL损害早期诊断的常规技术,它并不有效。