Verma Geetika, Kanawaty D, Hyland R
University of Toronto, Toronto, Canada.
Can Respir J. 2005 Jan-Feb;12(1):43-5. doi: 10.1155/2005/501457.
Rhinoscleroma is a chronic granulomatous condition of the respiratory tract, and is not uncommon in tropical regions; particularly, Mexico, Central America and the Middle East. A few cases have been reported in North America, primarily involving immigrants from endemic countries. The causative organism is Klebsiella rhinoscleromatis, a Gram-negative coccobacillus. Diagnosis is made on the basis of culture of the organism and the characteristic pathology of Mikulicz cells on light microscopy. The condition primarily affects the upper airway, and frequently presents with nasal discharge, nasal obstruction or frontal facial pain. Despite the term 'rhinoscleroma', there may be involvement of the entire respiratory tract. Although the condition is slowly progressive, its natural course portends extensive destruction. Laryngotracheal involvement occurs in approximately 15% to 80% of cases, but patients rarely present with isolated laryngotracheal disease. In the present paper, a case of rhinoscleroma presenting with symptoms of upper airway obstruction is described.
鼻硬结病是一种呼吸道慢性肉芽肿性疾病,在热带地区并不罕见,尤其是墨西哥、中美洲和中东地区。北美也有少数病例报告,主要涉及来自流行国家的移民。病原体是鼻硬结克雷伯菌,一种革兰氏阴性球杆菌。诊断基于该病原体的培养以及光镜下米库利奇细胞的特征性病理表现。该病主要影响上呼吸道,常表现为鼻分泌物、鼻塞或额面部疼痛。尽管名为“鼻硬结病”,但整个呼吸道都可能受累。虽然病情进展缓慢,但其自然病程预示着广泛的破坏。约15%至80%的病例会出现喉气管受累,但患者很少仅表现为孤立的喉气管疾病。本文描述了一例表现为上呼吸道梗阻症状的鼻硬结病病例。