安塔利亚地区土耳其冠心病患者对氧磷酶-1（PON1）活性与脂蛋白（a）水平之间的关系。
Relationship between paraoxonase-1 (PON1) activity and lipoprotein (a) levels in Turkish coronary artery disease patients living in the Antalya region.
作者信息
Göçmen Yeşim A, Semiz Ender, Gümüşlü Saadet
机构信息
Departments of aBiochemistry bCardiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
出版信息
Eur J Cardiovasc Prev Rehabil. 2005 Apr;12(2):185-6. doi: 10.1097/00149831-200504000-00016.
BACKGROUND
Turkish adults have a high incidence of coronary artery disease (CAD).
DESIGN
The role of lipoprotein(a) (Lp[a]) as a risk factor for CAD and its association with paraoxonase-1 (PON1) activity and lipid peroxidation indicators were evaluated in Turkish subjects living in Antalya.
METHODS
Paraoxonase-1 activity, Lp(a), conjugated dienes (CD) and thiobarbituric acid-reactive substances (TBARS) levels were measured in 45 healthy controls and 72 CAD patients.
RESULTS
In CAD patients, decreased PON1 activity and increased Lp(a), CD and TBARS levels were observed. Risk factors associated with CAD included TBARS, age and CD.
CONCLUSIONS
Our results indicate an association between PON1 activity and Lp(a) level in CAD patients.
背景
土耳其成年人冠状动脉疾病（CAD）的发病率很高。
设计
在居住于安塔利亚的土耳其受试者中，评估脂蛋白(a)（Lp[a]）作为CAD危险因素的作用及其与对氧磷酶-1（PON1）活性和脂质过氧化指标的关联。
方法
测量了45名健康对照者和72名CAD患者的对氧磷酶-1活性、Lp(a)、共轭二烯（CD）和硫代巴比妥酸反应性物质（TBARS）水平。
结果
在CAD患者中，观察到PON1活性降低，Lp(a)、CD和TBARS水平升高。与CAD相关的危险因素包括TBARS、年龄和CD。
结论
我们的结果表明CAD患者中PON1活性与Lp(a)水平之间存在关联。
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