Trisomboon Hataitip, Malaivijitnond Suchinda, Watanabe Gen, Taya Kazuyoshi
Department of Physiology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.
Endocrine. 2005 Feb;26(1):33-9. doi: 10.1385/ENDO:26:1:033.
Pueraria mirifica (PM), a Thai herb containing phytoestrogens, may act as estrogen and disturb reproduction. To investigate the effect of PM on the menstrual cycle length and related hormones, nine adult female monkeys (Macaca fascicularis) were separated into three groups. Each group (n = 3) was fed with 10, 100, and 1000 mg/d of PM for three menstrual cycles. The menstrual cycle length increased significantly in monkeys treated with PM-10 and PM-100 and disappeared completely in monkeys treated with PM-1000. Serum follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and irinhibin were lower during the treatment period in a dose-dependent manner. Changes in menstrual cycle length and the hormonal levels recovered during the post-treatment period only in monkeys treated with PM-10 and PM-100. PM greatly influences menstrual cycles and may suppress ovulation by lowering serum levels of gonadotropins.
白高颗（PM）是一种含有植物雌激素的泰国草药，可能会起到雌激素的作用并干扰生殖。为了研究PM对月经周期长度和相关激素的影响，将9只成年雌性猕猴（食蟹猴）分成三组。每组（n = 3）连续三个月经周期分别喂食10、100和1000毫克/天的PM。用PM - 10和PM - 100处理的猴子月经周期长度显著增加，而用PM - 1000处理的猴子月经周期完全消失。在治疗期间，血清促卵泡激素、促黄体生成素、雌二醇、孕酮和抑制素呈剂量依赖性降低。仅在用PM - 10和PM - 100处理的猴子中，治疗后月经周期长度和激素水平的变化才恢复。PM对月经周期有很大影响，可能通过降低血清促性腺激素水平来抑制排卵。
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