丝裂霉素C用于瘢痕疙瘩治疗的初步报告。

Use of mitomycin C for treatment of keloid: a preliminary report.

作者信息

Talmi Yoav P, Orenstein Arie, Wolf Michael, Kronenberg Jona

机构信息

Department of Otolaryngology--Head and Neck Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Otolaryngol Head Neck Surg. 2005 Apr;132(4):598-601. doi: 10.1016/j.otohns.2004.09.060.

DOI:10.1016/j.otohns.2004.09.060

PMID:15806053

Abstract

OBJECTIVES

Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision.

STUDY DESIGN AND SETTING

Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed.

RESULTS

All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm.

CONCLUSIONS

MC application following scar resection appears to be effective in treatment of keloid.

SIGNIFICANCE

As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome.

摘要