多发性硬化症患者血清对肺炎衣原体缺乏寡克隆抗体反应。

Lack of serum oligoclonal antibody responses to Chlamydophila pneumoniae in multiple sclerosis.

作者信息

Chapman M D, Hartley J C, Furrows S J, Ridgeway G L, Thompson E J, Church A J, Candler P M, Giovannoni G

机构信息

Department of Neuroimmunology, Institute of Neurology, Great Ormond Street Hospital, London, UK.

出版信息

Eur Neurol. 2005;53(2):81-3. doi: 10.1159/000084933. Epub 2005 Apr 5.

DOI:10.1159/000084933

PMID:15812167

Abstract

Chlamydophila pneumoniae has been proposed as an aetiological agent in MS via a mechanism involving molecular mimicry. We undertook to investigate whether the presence of CSF oligoclonal IgG OCB or oligoclonal bands correlated with serum IgG raised against C. pneumoniae. Paired serum and CSF of 19 MS patients and 27 control patients with other neurological diseases were studied by IEF and Western blotting. Only 1 of 19 MS patients had serum antibodies against C. pneumoniae compared with 2 of the 26 control patients. This was not significant, leading us to conclude that this study does not support the theory of an association between C. pneumoniae and MS.

摘要

肺炎衣原体已被提出是通过分子模拟机制成为多发性硬化症的一种病原体。我们着手研究脑脊液寡克隆IgG（OCB）或寡克隆带的存在是否与针对肺炎衣原体的血清IgG升高相关。通过等电聚焦（IEF）和蛋白质印迹法对19例多发性硬化症患者和27例患有其他神经系统疾病的对照患者的配对血清和脑脊液进行了研究。19例多发性硬化症患者中只有1例有针对肺炎衣原体的血清抗体，而26例对照患者中有2例有。这并无统计学意义，使我们得出结论，这项研究不支持肺炎衣原体与多发性硬化症之间有关联的理论。