Andreasyan K, Ponsonby A-L, Dwyer T, Kemp A, Dear K, Cochrane J, Carmichael A
National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia.
Allergy. 2005 May;60(5):671-7. doi: 10.1111/j.1398-9995.2005.00757.x.
We examined the role of fish intake in the development of atopic disease with particular reference to the possibility of differential effects on allergen-specific subgroups of sensitization.
The exposure of interest was parental report of fish intake by children aged 8 years at the 1997 Childhood Allergy and Respiratory Health Study (n = 499). The outcomes of interest were subgroups of atopy: house dust mite (HDM)-pure sensitization [a positive skin-prick test (SPT) > or = 2 mm to Der p or Der f only], ryegrass-pure sensitization (a positive SPT > or = 2 mm to ryegrass only); asthma and hay fever by allergen-specific sensitization.
A significant association between fish intake and ryegrass-pure [adjusted odds ratio (AOR) 0.37 (0.15-0.90)] but not HDM-pure sensitization [AOR 0.87 (0.36-2.13)] was found. Fish consumption significantly decreased the risk for ryegrass-pure sensitization in comparison with HDM-pure sensitization [AOR 0.20 (0.05-0.79)].
We have demonstrated a differential effect of fish intake for sensitization to different aeroallergens. This may be due to the different timing of allergen exposure during early life. Further investigation of the causes of atopic disease should take into account allergen-specific subgroups.
我们研究了鱼类摄入在特应性疾病发生发展中的作用，特别关注其对致敏原特异性致敏亚组可能产生的不同影响。
研究对象为1997年儿童过敏与呼吸健康研究中8岁儿童的鱼类摄入情况（通过家长报告，n = 499）。研究的结局指标为特应性亚组：单纯屋尘螨（HDM）致敏[对Der p或Der f的皮肤点刺试验（SPT）阳性且≥2 mm]、单纯黑麦草致敏（对黑麦草的SPT阳性且≥2 mm）；以及根据致敏原特异性致敏情况划分的哮喘和花粉症。
发现鱼类摄入与单纯黑麦草致敏之间存在显著关联[调整优势比（AOR）为0.37（0.15 - 0.90）]，但与单纯HDM致敏无显著关联[AOR为0.87（0.36 - 2.13）]。与单纯HDM致敏相比，食用鱼类显著降低了单纯黑麦草致敏的风险[AOR为0.20（0.05 - 0.79）]。
我们已证明鱼类摄入对不同气传变应原致敏有不同影响。这可能是由于生命早期变应原暴露时间不同所致。特应性疾病病因的进一步研究应考虑致敏原特异性亚组。
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