Herth Felix, Ernst Armin, Becker Heinrich D
Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Rd, Boston, MA 02115, USA.
Chest. 2005 Apr;127(4):1378-81. doi: 10.1378/chest.127.4.1378.
Lung abscesses commonly respond well to antibiotic therapy. In patients in whom conventional therapy fails, either percutaneous catheter drainage or surgical resection are usually considered, but are frequently problematic. This study describes our experience with endoscopic lung abscess drainage in patients in whom antibiotic therapy fails.
Patients in whom antibiotic therapy for lung abscess (enlarging cavity or lack of improvement of clinical status) was unsuccessful were considered candidates if an airway connection to the cavity was present. Treatment decisions were made in a multidisciplinary chest conference. Pigtail catheters were placed via a guidewire approach into the cavities. The abscesses were flushed twice daily with gentamycin solution. If fungal infection was suspected, once-daily amphotericin B was added to the regimen.
Forty-two patients, from January 2000 to May 2002 (17 woman and 25 men) were included in this study (mean age, 48.9 years). Catheter placement was successful in 38 patients and led to successful therapy after a mean of 6.2 days of treatment (range, 3 to 21 days). Two patients required transient ventilation after catheter placement; there were no other complications.
Endoscopic lung abscess drainage in selected patients in whom antibiotic therapy fails is feasible and successful in experienced hands. This treatment represents an additional option for the chest physician other than percutaneous catheter drainage or surgical resection.
肺脓肿通常对抗生素治疗反应良好。对于常规治疗失败的患者,通常会考虑经皮导管引流或手术切除,但这些方法常常存在问题。本研究描述了我们在抗生素治疗失败的患者中进行内镜下肺脓肿引流的经验。
如果肺脓肿患者(空洞扩大或临床状况无改善)对抗生素治疗无效且气道与空洞相通,则将其视为内镜下肺脓肿引流的候选者。治疗决策在多学科胸部会议上做出。通过导丝引导将猪尾导管置入空洞。每天用庆大霉素溶液冲洗脓肿两次。如果怀疑有真菌感染,则在治疗方案中加用每日一次的两性霉素B。
本研究纳入了2000年1月至2002年5月期间的42例患者(17例女性和25例男性)(平均年龄48.9岁)。38例患者导管置入成功,平均治疗6.2天(3至21天)后治疗成功。2例患者在导管置入后需要短暂通气;无其他并发症。
对于抗生素治疗失败的特定患者,内镜下肺脓肿引流在经验丰富的医生手中是可行且成功的。这种治疗方法为胸科医生提供了除经皮导管引流或手术切除之外的另一种选择。