伤口愈合的观点。

Wound-healing perspectives.

作者信息

Li Wei, Dasgeb Bahar, Phillips Tania, Li Yong, Chen Mei, Garner Warren, Woodley David T

机构信息

University of Southern California Dermatology, Norris Cancer Center, Keck School of Medicine, Los Angeles, 90033, USA.

出版信息

Dermatol Clin. 2005 Apr;23(2):181-92. doi: 10.1016/j.det.2004.09.004.

DOI:10.1016/j.det.2004.09.004

PMID:15837149

Abstract

Wound-healing in the skin is a complex orchestration of cellular processes, which has been perfected throughout the eons of phylogeny. It has so many coordinated biologic processes invoked both simultaneously and in a regulated orderly fashion that it has been likened to a recapitulation of gestation. Part of the problem with studying wound healing is in analyzing the processes independently and then seeing how they fit together and influence each other. This article discusses selected and recent scientific observations that have given insight into the biology of human skin wound healing. The article then discusses selected clinical advances that are based less on evidence-based observation and more on what works in practice and promotes wound healing.

摘要

皮肤伤口愈合是细胞过程的复杂协调，这在漫长的系统发育过程中已臻完善。它有如此多协调的生物过程，同时以有序且受调控的方式被激活，以至于被比作妊娠的重演。研究伤口愈合的部分问题在于独立分析这些过程，然后观察它们如何相互配合和相互影响。本文讨论了一些近期的科学观察结果，这些观察为人类皮肤伤口愈合的生物学机制提供了见解。然后本文讨论了一些临床进展，这些进展较少基于循证观察，更多基于实践中有效的方法并能促进伤口愈合。